What is Intrahepatic Cholestasis of Pregnancy?

February 08, 2023

Women's Health
Pregnant women itching belly
Intrahepatic cholestasis of pregnancy – or ICP – is the most common liver condition that happens during pregnancy. “Under normal circumstances, bile acid flows from your liver to your gut to help process food. However, in women with ICP, the bile acid doesn’t flow properly, causing components of bile to build up in your body,” explains Jerrid Neeley, D.O., an OB-GYN with Riverside Partners in Women’s Health.

Causes of ICP

Experts continue to research the exact cause of ICP. However, they believe that the following factors may play a role:

  • Certain genetic traits, including South Asian heritage
  • Certain environmental factors, such as where you live and the seasons of the year
  • Rising hormones during late pregnancy

Symptoms and signs of ICP

In most women, the signs and symptoms of this condition begin around 28 weeks of gestation. The primary sign of ICP is itchy skin, without any rash. “The itchy feeling is often worse on the hands and feet, but it can occur anywhere on the body,” says Dr. Neeley. Many women experience increased itchiness at nighttime.

Other symptoms of ICP can include:

  • Dark-colored urine
  • Decreased appetite
  • Jaundice (yellowing of the whites of the eyes and skin)
  • Nausea
  • Unusual smelling, oily stool

Diagnosis of ICP

To diagnose this condition, your doctor will likely:

  • Ask you questions about your current symptoms related to ICP
  • Ask you questions about your medical history 
  • Do a physical exam to check for signs of ICP
  • Run a blood test to check the bile acid levels in your blood and determine if your liver is functioning normally

How will ICP Affect My Pregnancy and My Baby?

Some research has found that having ICP increases your risk of delivering your baby premature, including in rare cases stillbirth.  Your OB-GYN may recommend early delivery of your baby around 37-39 weeks, or as early as 36 weeks, to reduce the risk of stillbirth.

How long does ICP last?

Though most women do not experience the symptoms of ICP until 28 weeks of gestation, the condition lasts throughout your pregnancy but should go away a few days after your baby is born.

Will I have ICP every pregnancy?

“Women who develop ICP during one pregnancy have a high likelihood of developing the condition again during subsequent pregnancies,” says Dr. Neeley.

Treatment for ICP

There’s no cure for ICP, so treatments focus on managing symptoms. Your doctor may recommend one or more of the following ways to manage your ICO symptoms:

  • Ongoing monitoring. If you have ICP, your doctor will recommend regular liver blood tests and bile acid measurement checks. Depending on your exact situation, you may need these tests as often as weekly.
  • Topical remedies for itch. Your doctor may recommend taking a cool bath or using scent-free lotion to help reduce your itchy feeling. You can also avoid perfumes or scented lotions which can further irritate your skin.
  • Comfortable natural fabrics. To further reduce irritated skin, your doctor may recommend you wear loose clothing made from natural materials, such as 100% cotton.
  • Prescription medication.  Your health care provider may prescribe you a medication, such as Ursodiol) that can help with itching.  This medication can also help protect your unborn baby and improve outcomes.

Make an Appointment

If you think you may have ICP or need help managing your condition, schedule an appointment with a Riverside Health System provider. 

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