Factor V deficiency: Is it inherited?

Factor V deficiency — sometimes called parahemophilia X — is a rare, inherited bleeding disorder. It's caused by inadequate levels of clotting factor V due to a gene defect. This defect is inherited in an autosomal recessive manner. This means a child must inherit two defective genes — one from each parent — to develop the disease.

A deficiency of factor V delays or slows clotting and can result in excessive bleeding. Bleeding can range from mild to severe and may include:

• Bleeding into the skin
• Easy bruising
• Nosebleeds
• Excessive menstrual bleeding
• Excessive bleeding with surgery or injury
• Bleeding of the gums

A doctor can confirm a diagnosis of factor V deficiency by special blood tests. There's no cure for this disorder. Blood transfusions temporarily correct the deficiency. During bleeding episodes, blood transfusions may be needed daily.