Combined inhibitors and blockers — Learn about this type of antidepressant and its side effects.
Certain brain chemicals called neurotransmitters are associated with depression, including the neurotransmitters serotonin (ser-oh-TOE-nin) and norepinephrine (nor-ep-ih-NEF-rin). Research suggests that abnormalities in neurotransmitter activity can affect mood and behavior.
How combined reuptake inhibitors and receptor blockers work
Combined reuptake inhibitors and receptor blockers are dual-action antidepressants. That is, they act on brain cells in two ways — both by inhibiting the reabsorption (reuptake) of neurotransmitters into nerve cells and by blocking nerve cell receptors. This leaves more of these neurotransmitters available in the brain, thereby boosting mood.
Combined reuptake inhibitors and receptor blockers approved to treat depression
Here are the combined inhibitors and blockers that have been approved by the Food and Drug Administration specifically to treat depression:
- Trazodone
- Nefazodone
- Maprotiline
These antidepressants are available only in generic form. The brand-name versions have been withdrawn from the market for various reasons.
Some of these medications may also be used to treat conditions other than depression.
Last Updated: 12/08/2006
