Marijuana as medicine: Consider the pros and cons
Marijuana as medicine: Consider the pros and cons
Marijuana — Understand the facts about using marijuana for nausea, pain and other medical problems.
People have used marijuana as a medical treatment for thousands of years. Such uses extend even to modern America. Marijuana was listed by the U.S. Pharmacopeia, the organization that sets quality standards for approved drugs in the United States, until the 1940s, when political pressure against marijuana's recreational use triggered its removal.
Despite the U.S. Supreme Court's ruling that state laws allowing medicinal use of marijuana must bow to federal law banning it, proponents still tout this controversial plant's ability to treat pain, nausea and other uncomfortable side effects of medical treatment as well as some disease symptoms.
Marijuana 101: The plant and its components
Marijuana refers to the dried flowers, leaves, stems and seeds of the Cannabis sativa plant. These parts contain the compounds that produce the mind-altering effect that recreational users seek when smoking or ingesting the plant — but they also provide components with potential medical benefits.
Marijuana contains at least 60 chemicals called cannabinoids. Researchers are evaluating how effective some of these cannabinoids might be in controlling symptoms of certain medical conditions. For example:
How it works
When smoked or ingested, THC and other cannabinoids in marijuana attach to two types of receptors on cells in your body — like keys in a lock — affecting the cells, once attached.
CB1 is one such receptor. CB1 receptors are found mainly in your brain, especially in areas that control body movement, memory and vomiting. This helps explain why marijuana use affects balance and coordination and impairs short-term memory and learning, and why it can be useful in treating nausea, pain and loss of appetite.
The other type of receptor, CB2, is found in small numbers elsewhere in your body, mainly in tissue of the immune system, such as your spleen and lymph nodes. The function of these receptors is not well understood. They may serve as brakes on immune system function, which may help explain why marijuana suppresses your immune system.
After you smoke marijuana, its ingredients reach their peak levels in your body within minutes, and effects can last up to an hour and a half. When eaten — the plant is sometimes mixed with food — the ingredients can take several hours to reach their peak levels in your body, and their effects may last for hours.
The prescription drug dronabinol, which is taken as an oral capsule, takes effect in about 30 minutes and can continue to stimulate appetite for more than a day.
Possible medical uses
Scientists studying marijuana's potential medical uses have found that it may help treat a variety of conditions.
Younger people may find marijuana more useful as a treatment for nausea than do older people — who may not tolerate its mind-altering side effects as well. The prescription form, dronabinol, also may produce psychological side effects that make it inappropriate for some older people. Doctors generally prescribe several kinds of newer anti-nausea drugs with fewer side effects before resorting to dronabinol.
In the early 1970s, scientists discovered that smoking marijuana reduced pressure in the eyes. Exactly how the cannabinoids in marijuana produce this effect isn't known. Scientists have discovered CB1 receptors in the eyes, which may provide clues for future research on how marijuana affects glaucoma.
Your doctor can prescribe other medications to treat glaucoma, but these can lose their effectiveness over time. Researchers are working to develop medications containing cannabinoids that can be put directly on the eyes — to avoid the mind-altering side effects and other health consequences of smoking the plant.
Researchers currently are developing new medications based on cannabis to treat pain.
Some scientists feel that more research may show cannabinoids useful in treating MS. Marijuana may protect nerves from the kind of damage that occurs during the disease. They also suggest that animal study results, knowledge of CB1 receptors in the brain and users' reports of decreased symptoms after using marijuana support this possibility. However, others advise caution in using marijuana to treat MS, given the modest therapeutic effects cannabinoids have demonstrated so far and the potential of long-term adverse side effects.
Not without risks
Though some doctors and patients suggest marijuana has a legitimate use, the United States government disagrees. Federal law recognizes marijuana as a Schedule I drug, which classifies it as one of "the most dangerous drugs that have no recognized medical use." If law-enforcement officers find you with the drug in your possession, the penalty can range from a small fine to a prison sentence.
Along with the legal implications, smoking marijuana poses several health risks, including:
Also, marijuana smoke contains 50 percent to 70 percent more carcinogenic hydrocarbons than does tobacco smoke and has the potential to cause cancer of the lungs and respiratory tract. Marijuana smoke is commonly inhaled deeper and held longer than is tobacco smoke, increasing the lungs' exposure to carcinogens.
These risks should be taken into account when considering the use of marijuana for medical purposes. If you are experiencing uncomfortable symptoms or side effects of medical treatment, especially pain and nausea, talk to your doctor about all your options before trying marijuana.
Last Updated: 08/25/2006
© 1998-2015 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "MayoClinic.com," "Mayo Clinic Health Information," "Reliable information for a healthier life" and the triple-shield Mayo logo are trademarks of Mayo Foundation for Medical Education and Research.
Terms and conditions of use